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AIDS

AIDS is an acronym for Acquired Immune Deficiency Syndrome:

• Acquired means you can get infected with it.
• Immune Deficiency means a weakness in the body's system that fights diseases.
• Syndrome means a group of health problems that make up a disease.

This is a picture of HIV. This image represents the structure of human immunodeficiency virus (HIV). HIV is part of a family or group of viruses called lentiviruses. Lentiviruses other than HIV have been found in a wide range of nonhuman primates. These other lentiviruses are known collectively as simian (monkey) viruses (SIV) where a subscript is used to denote their species of origin.

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A blood test for HIV looks for these antibodies. If you have them in your blood, it means that you have HIV infection. People who have the HIV antibodies are called "HIV-Positive."

AIDS is caused by a virus called HIV, the Human Immunodeficiency Virus. If you get infected with HIV, your body will try to fight the infection. It will make "antibodies" -- special molecules to fight HIV.

Being HIV-positive, or having HIV disease, is not the same as having AIDS. Many people are HIV-positive but don't get sick for many years. As HIV disease continues, it slowly wears down the immune system. Viruses, parasites, fungi and bacteria that usually don't cause any problems can make you very sick if your immune system is damaged. These are called "opportunistic infections."

How is AIDS acquired?

You don't actually "get" AIDS. You might get infected with HIV, and later you might develop AIDS. You can get infected with HIV from anyone who's infected, even if they don't look sick and even if they haven't tested HIV-positive yet. The blood, vaginal fluid, semen, and breast milk of people infected with HIV has enough of the virus in it to infect other people. Most people get the HIV virus by:

• having sex with an infected person.
• sharing a needle (shooting drugs) with someone who's infected
• being born when their mother is infected, or drinking the breast milk of an infected woman.

This is a picture of a HIV. The green particles are the HIV infecting the T helper cells. HIV infects the T Helper cell because it has the protein CD4 on its surface. HIV needs to use CD4 to enter cells it infects. This is why the T helper cell is referred to as a CD4 lymphocyte. Once inside a T helper cell, HIV takes over the cell and the virus then replicates. In this process (which takes around a couple of days) the infected cell dies. New virus then seeks out new T -helper cells to infect.

Getting a transfusion of infected blood used to be a way people got AIDS, but now the blood supply is screened very carefully and the risk is extremely low.

• There are no documented cases of HIV being transmitted by tears or saliva, but it is possible to be infected with HIV through oral sex or in rare cases through deep kissing, especially if you have open sores in your mouth or bleeding gums.

The Centers for Disease Control and Prevention (CDC) estimates that 850,000 to 950,000 U.S. residents are living with HIV infection, one-quarter of whom are unaware of their infection. Almost 400,000 people are living with AIDS. Each year, there are about 40,000 new infections. Of these, about 70 percent are among men and 30 percent among women. Half of these newly infected people are younger than 25 years of age. In the mid-1990s, AIDS was a leading cause of death. However, newer treatments have cut the AIDS death rate significantly. For more information, see the U.S. Government fact sheet at www.niaid.nih.gov/factsheets/aidsstat.htm.

If you’re HIV positive

You might not know if you get infected by HIV. Some people get fever, headache, sore muscles and joints, stomach ache, swollen lymph glands, or a skin rash for one or two weeks. Most people think it's the flu. Some people have no symptoms.

This is a picture of HIV structure. This picture represents the structure of HIV and how the HIV is organised. HIV is part of a family or group of viruses called lentiviruses. Lentiviruses other than HIV have been found in a wide range of nonhuman primates. These other lentiviruses are known collectively as simian (monkey) viruses (SIV) where a subscript is used to denote their species of origin.

The virus will multiply in your body for a few weeks or even months before your immune system responds. During this time, you won't test positive for HIV, but you can infect other people.

When your immune system responds, it starts to make antibodies. When this happens, you will test positive for HIV. After the first flu-like symptoms, some people with HIV stay healthy for ten years or longer. But during this time, HIV is damaging your immune system. One way to measure the damage to your immune system is to count your CD4+ cells. These cells, also called "T-helper" cells, are an important part of the immune system. Healthy people have between 500 and 1,500 CD4+ cells in a milliliter of blood.

Without treatment, your CD4+ cell count will most likely go down. You might start having signs of HIV disease like fevers, night sweats, diarrhea, or swollen lymph nodes. If you have HIV disease, these problems will last more than a few days, and probably continue for several weeks.

How does one know if they have AIDS?

HIV disease becomes AIDS when your immune system is seriously damaged. If you have less than 200 CD4+ cells or if your CD4+ percentage is less than 14%, you have AIDS. If you get an opportunistic infection, you have AIDS. There is an "official" list of opportunistic infections, put out by the Centers for Disease Control (CDC). The most common ones are:

• PCP (Pneumocystis pneumonia), a lung infection,
• KS (Kaposi's sarcoma), a skin cancer,
• CMV (Cytomegalovirus), an infection that usually affects the eyes, and
• Candida, a fungal infection that can cause thrush (a white film in your mouth) or infections in your throat or vagina,

AIDS is different in every infected person. Some people die in a few months after getting infected, while others live fairly normal lives for many years, even after they "officially" have AIDS. A few HIV-positive people stay healthy for many years even without taking anti-HIV medications.

AIDS-related diseases also include serious weight loss, brain tumors, and other health problems. Without treatment, these opportunistic infections can kill you. The official CDC definition of AIDS is available at
www.cdc.gov/mmwr/preview/mmwrhtml/00018871.htm.

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